2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1830):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0016S
    Capecitabine-d11
    		Inhibitor 99%
    Capecitabine-d11 is the deuterium labeled Capecitabine. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.
    Capecitabine-d<sub>11</sub>
  • HY-110407
    2'-O,4'-C-Methyleneadenosine
    2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog.
    2'-O,4'-C-Methyleneadenosine
  • HY-W017749
    1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil
    		≥98.0%
    1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a purine nucleoside analogue with antiviral activity.
    1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil
  • HY-102026
    Formycin A
    		≥99.0%
    Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM. Formycin A shows antitumor and antiviral activities.
    Formycin A
  • HY-134160
    5,6-Dihydro-5-Fluorouracil
    		99.90%
    5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50=13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model.
    5,6-Dihydro-5-Fluorouracil
  • HY-138586
    DMT-dC(ac) Phosphoramidite
    		99.76%
    DMT-dC(ac) Phosphoramidite (compound 30f) is a phosphoramidite derivative that can be used for the oligonucleotide synthesis.
    DMT-dC(ac) Phosphoramidite
  • HY-W013195
    8-Bromoadenosine
    		99.68%
    8-Bromoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. 8-Bromoadenosine can quench the intrinsic fluorescence of human serum albumin (HSA) through static quenching procedure. 8-Bromoadenosine can be used to synthesize adenosine phosphate, such as Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    8-Bromoadenosine
  • HY-W013289
    2'-O-Methylinosine
    		99.27%
    9-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-ol (2'-O-methylinosine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2'-O-Methylinosine
  • HY-77652
    Nucleoside-Analog-2
    Nucleoside-Analog-2 is a 4'-Azidocytidine analogue against Hepatitis C virus (HCV) replication. Nucleoside-Analog-2 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Nucleoside-Analog-2
  • HY-123523
    Enocitabine
    		99.32%
    Enocitabine is a nucleoside analog, and is a potent DNA replication inhibitor, and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus. Enocitabine has antileukemic and antiviral activities.
    Enocitabine
  • HY-138580
    2'-OMe-A(Bz) Phosphoramidite
    		99.74%
    2'-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
    2'-OMe-A(Bz) Phosphoramidite
  • HY-152334
    2’-Chloro-2’-deoxyadenosine
    		98.53%
    2’-Chloro-2’-deoxyadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Chloro-2’-deoxyadenosine
  • HY-W393317
    5-Methoxycarbonylmethyl-2'-O-methyluridine
    		99.80%
    5-Methoxycarbonylmethyl-2'-O-methyluridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    5-Methoxycarbonylmethyl-2'-O-methyluridine
  • HY-W019033
    8-Bromoguanosine
    		99.99%
    8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function.
    8-Bromoguanosine
  • HY-116887
    N6-Methyladenine
    		98.79%
    N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication.
    N6-Methyladenine
  • HY-W013077
    N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
    		≥98.0%
    N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine can be used as an intermediate.
    N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
  • HY-W115309
    DMT-2'-F-iBu-G
    DMT-2'-F-iBu-G (5'-DMT-2'-F-ibu-dG) is a modified oligonucleotide. 2'-deoxy-2'-fluoro-modified oligonucleotides shows high nuclease resistant and retained exceptional binding affinity to the RNA targets.
    DMT-2'-F-iBu-G
  • HY-W025438
    5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine
    		98.03%
    5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine
  • HY-W102322
    5'-O-DMT-2'-TBDMS-Uridine
    		99.11%
    5'-O-DMT-2'-TBDMS-Uridine is a deoxyribonucleoside used for the oligonucleotide synthesis.
    5'-O-DMT-2'-TBDMS-Uridine
  • HY-W394106
    5-Hydroxymethyl uridine
    		≥98.0%
    5-Hydroxymethyl uridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    5-Hydroxymethyl uridine